Learning to change: the role of organisational capabilities in industry response to environmental regulation.

This thesis looks at the potential for environmental regulation to induce economically beneficial technical change in industrial activity. This question is explored in the context of the recent introduction of Irish legislation aimed at promoting such technical change. The research focuses on the experience of one industrial sector, the pharmaceutical manufacturing sector, in making the adjustment to the new Integrated Pollution Control regulations. The key question of interest is the importance of organisational capabilities in determining firms’ ability to adjust to a changed regulatory environment, to develop new organisational processes and to implement technical change. The thesis presents an analysis of competing theoretical approaches to analysis of regulation and technical change. The evolutionary theory of the firm, with its emphasis on organisational capabilities as the driver of technical change in firms, is identified as the most appropriate framework for the development of a coherent model of the relationship between environmental regulation and firm technical change. The empirical research was undertaken using two, complementary approaches. Measures of capability were constructed for all pharmaceutical firms licensed in the first phase of IPC implementation. This allows for comparative analysis of the role of organisational capabilities in the sector’s response to new environmental regulations. Further analysis of questions around the origins, significance and contingent nature of capabilities is explored in qualitative, case study research in five selected case companies. The research presented in this dissertation show that firms are differentially able to respond to technology-forcing regulations and that these differences are associated with differences in organisational capabilities. Firms with high performing dynamic capability were able to ensure effective environmental performance, preserving flexibility of action and supporting overall competitiveness

Environmental performance and practice across sectors : methodology and preliminary results

Abstract: This paper introduces a methodology for measuring and modeling manufacturers' environmental performance and the managerial and technological practices that affect it. Facility level licensing data from the Irish Environmental Protection Agency are used to develop indicators that can be analysed across sectors, addressing the problem that environmental performance and determinants tend to be sector-specific, while modeling and policy interests are often more general. Using Integrated Pollution Control (IPC) information generated EU-wide , this approach should be capable of cross-country extension. The methodology is tested on a sample of Irish facilities in three sectors during 1996-2004. Preliminary results show its usefulness in exploring the determinants of environmental performance at the sector and cross-sector levels, and suggest potential uses in future research

Environmental performance and practice across sectors : methodology and preliminary results

Abstract: This paper introduces a new methodology for measuring and modelling manufacturers" environmental performance and the managerial and technological practices that affect it. Facility level licensing data are used to develop indicators based on sector-specific criteria but capable of being analysed across sectors, at various levels of aggregation. This addresses the problem that environmental performance and determinants tend to be highly context-specific, while modelling and policy interests are often more general. Using Integrated Pollution Control (IPC) information generated EUwide, this approach should be capable of cross-country extension. The methodology is tested on a sample of Irish facilities in three sectors during 1996-2004. Preliminary results show its usefulness in exploring the determinants of environmental performance at the sector and cross-sector levels. Word count = 10,049

How Knowledge Transfer Impact Happens at the Farm Level: Insights from Advisers and Farmers in the Irish Agricultural Sector

Many studies show that interaction with agricultural advisory services impacts productivity and profitability on farms. However, less attention is paid to explaining how this impact is achieved. This paper explores the factors that determine the implementation of newly learned knowledge from advisory engagement to achieve an impact on farm level performance. Focusing on the Irish case, a series of semi-structured interviews from a purposive sample of advisers and farmers from the more profitable dairy sector were undertaken to analyse the key drivers of impact. Results show that a combination of group-based and individual activities based on relevant content focused on key management practices for grassland, breeding, and financial management were key to achieving impact. Furthermore, positive outcomes were dependent on a high degree of trust between the farmer and the organisation, between the farmer and the adviser, and between the farmer and their peers. The findings indicate that while some barriers remain for farmers to apply newly learned knowledge, those that do implement the practices report a positive impact. This has implications for knowledge transfer design which is timely given the focus on these activities in the upcoming Common Agricultural Policy 2023–2027

How Knowledge Transfer Impact Happens at the Farm Level: Insights from Advisers and Farmers in the Irish Agricultural Sector

Many studies show that interaction with agricultural advisory services impacts productivity and profitability on farms. However, less attention is paid to explaining how this impact is achieved. This paper explores the factors that determine the implementation of newly learned knowledge from advisory engagement to achieve an impact on farm level performance. Focusing on the Irish case, a series of semi-structured interviews from a purposive sample of advisers and farmers from the more profitable dairy sector were undertaken to analyse the key drivers of impact. Results show that a combination of group-based and individual activities based on relevant content focused on key management practices for grassland, breeding, and financial management were key to achieving impact. Furthermore, positive outcomes were dependent on a high degree of trust between the farmer and the organisation, between the farmer and the adviser, and between the farmer and their peers. The findings indicate that while some barriers remain for farmers to apply newly learned knowledge, those that do implement the practices report a positive impact. This has implications for knowledge transfer design which is timely given the focus on these activities in the upcoming Common Agricultural Policy 2023–2027

You Can Quit Me But I’m Not Going to Quit You:” A Focus Group Study of Leaders’ Perceptions of Their Positive Influences on Youth in Boy Scouts of America

As part of a longitudinal, mixed-method study with Boy Scouts of America, we conducted five focus groups with a diverse group of 46 program leaders in order to better understand their perceptions of how they influence youth. Drawing from grounded theory analysis methods, we found that leaders believed they promoted positive youth outcomes, including character and self-confidence, through caring youth-leader relationships and facilitating opportunities for youth to participate in and lead skill-building activities and apply skills in different contexts. Leaders differed in the particular outcomes that they emphasized. Implications of these findings for future research and practice are discussed

Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule

Circulating tumor cells consist of phenotypically distinct subpopulations that originate from the tumor microenvironment. We report a circulating tumor cell dual selection assay that uses discrete microfluidics to select circulating tumor cell subpopulations from a single blood sample; circulating tumor cells expressing the established marker epithelial cell adhesion molecule and a new marker, fibroblast activation protein alpha, were evaluated. Both circulating tumor cell subpopulations were detected in metastatic ovarian, colorectal, prostate, breast, and pancreatic cancer patients and 90% of the isolated circulating tumor cells did not co-express both antigens. Clinical sensitivities of 100% showed substantial improvement compared to epithelial cell adhesion molecule selection alone. Owing to high purity (>80%) of the selected circulating tumor cells, molecular analysis of both circulating tumor cell subpopulations was carried out in bulk, including next generation sequencing, mutation analysis, and gene expression. Results suggested fibroblast activation protein alpha and epithelial cell adhesion molecule circulating tumor cells are distinct subpopulations and the use of these in concert can provide information needed to navigate through cancer disease management challenges

Program Innovations and Character in Cub Scouts: Findings from Year 1 of a Mixed-Methods, Longitudinal Study

Youth development programs seek to promote positive development through mentoring and engaging youth in opportunities for individual growth and community connectedness. We present findings from the initial phase of a mixed-methods, longitudinal study aimed at assessing the impact of one such program, Cub Scouts, on character development. We assessed if Scouting, and a recent innovation in Scouting focused on program quality, are associated with the development of character and other positive youth outcomes. Participants were 1,083 Scouts and non-Scouts, aged 5-12 years. At the start of the study, there was no difference in indicators of character between Scouts and non-Scouts, once matched through propensity score analyses. Through content analyses of interviews and short- answer questionnaires administered to leaders, we found that leaders’ views of character and of their roles corresponded to those envisioned by Cub Scouts. Implications for character development, and for the role of program components in character development, are discussed

A scoping review of ‘Pacing’ for management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): lessons learned for the long COVID pandemic

Background: Controversy over treatment for people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a barrier to appropriate treatment. Energy management or pacing is a prominent coping strategy for people with ME/CFS. Whilst a definitive definition of pacing is not unanimous within the literature or healthcare providers, it typically comprises regulating activity to avoid post exertional malaise (PEM), the worsening of symptoms after an activity. Until now, characteristics of pacing, and the effects on patients’ symptoms had not been systematically reviewed. This is problematic as the most common approach to pacing, pacing prescription, and the pooled efficacy of pacing was unknown. Collating evidence may help advise those suffering with similar symptoms, including long COVID, as practitioners would be better informed on methodological approaches to adopt, pacing implementation, and expected outcomes. Objectives: In this scoping review of the literature, we aggregated type of, and outcomes of, pacing in people with ME/CFS. Eligibility criteria: Original investigations concerning pacing were considered in participants with ME/CFS. Sources of evidence: Six electronic databases (PubMed, Scholar, ScienceDirect, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials [CENTRAL]) were searched; and websites MEPedia, Action for ME, and ME Action were also searched for grey literature, to fully capture patient surveys not published in academic journals. Methods: A scoping review was conducted. Review selection and characterisation was performed by two independent reviewers using pretested forms. Results: Authors reviewed 177 titles and abstracts, resulting in 17 included studies: three randomised control trials (RCTs); one uncontrolled trial; one interventional case series; one retrospective observational study; two prospective observational studies; four cross-sectional observational studies; and five cross-sectional analytical studies. Studies included variable designs, durations, and outcome measures. In terms of pacing administration, studies used educational sessions and diaries for activity monitoring. Eleven studies reported benefits of pacing, four studies reported no effect, and two studies reported a detrimental effect in comparison to the control group. Conclusions: Highly variable study designs and outcome measures, allied to poor to fair methodological quality resulted in heterogenous findings and highlights the requirement for more research examining pacing. Looking to the long COVID pandemic, our results suggest future studies should be RCTs utilising objectively quantified digitised pacing, over a longer duration of examination (i.e. longitudinal studies), using the core outcome set for patient reported outcome measures. Until these are completed, the literature base is insufficient to inform treatment practises for people with ME/CFS and long COVID